Description

• General description: [6]-Gingerol is implicated in apoptosis, cell cycle regulation, cytotoxic activity and inhibition of angiogenesis.[1] It prevents serotonin release and platelet aggregation.[2] Gingerol has immunomodulatory, antiapoptotic, antihyperglycemic, antilipidemic and antiemetic properties.[2]
• Application: [6]-Gingerol has been used:to study its effects on transient receptor potential (TRP) channels[3]to study its effects on experimental models of non-alcoholic steatohepatitis[4]to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line[5]to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice[6]
• Biochem/physiol Actions: Bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.