Sulindac
≥98.0%
Manufacturer: Sigma Aldrich
CAS Number: 38194-50-2
Synonym(S): (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 G | S8139-5-G | In Stock | ₹ 10,197.15 |
| 25 G | S8139-25-G | In Stock | ₹ 39,879.30 |
S8139 - 5 G
In Stock
Quantity
1
Base Price: ₹ 10,197.15
GST (18%): ₹ 1,835.487
Total Price: ₹ 12,032.637
biological source
synthetic (organic)
Quality Level
200
Assay
≥98.0%
form
powder
technique(s)
HPLC: suitablegas chromatography (GC): suitable
solubility
methanol: 50 mg/mL
application(s)
forensics and toxicologyveterinary
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O
InChI
1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sulindac | Supelco | ₹ 24,756.78 | |
| | Sulindac | Sigma Aldrich | ₹ 23,133.03 | |
| | Sulindac | Sigma Aldrich | ₹ 13,964.25 | |
| | Sulindac for system suitability | Sigma Aldrich | ₹ 14,970.98 |
Description
- Application: Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin in vitro28 and its ability to bind to human plasma protein.29
- Biochem/physiol Actions: Sulindac is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells25,26 and reduces tumor burden in adenomatous polyposis patients.27
- Features and Benefits: This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
biological source: synthetic (organic)
Quality Level: 200
Assay: ≥98.0%
form: powder
technique(s): HPLC: suitablegas chromatography (GC): suitable
solubility: methanol: 50 mg/mL
application(s): forensics and toxicologyveterinary
originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O
InChI: 1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
biological source: __
Quality Level: 200
Assay: >99% (titration)
form: solid
technique(s): __
solubility: H2O: 1 M at 20 °C, clear, colorless
application(s): __
originator: __
SMILES string: __
InChI: __
biological source: __
Quality Level: 200
Assay: ≥99.0%
form: __
technique(s): __
solubility: H2O: 1 M at 20 °C, clear, colorless
application(s): __
originator: __
SMILES string: [Na+].[O-][N+]([O-])=O
InChI: 1S/NO3.Na/c2-1(3)4;/q-1;+1
