52853

7α-Hydroxy-4-cholesten-3-one

≥95.0% (HPLC)

Manufacturer: Supelco

CAS Number: 3862-25-7

Synonym(S): 7α-Hydroxycholest-4-en-3-one

Select a Size

Pack Size SKU Availability Price
1 MG 52853-1-MG In Stock ₹ 33,741.53

52853 - 1 MG

₹ 33,741.53

In Stock

Quantity

1

Base Price: ₹ 33,741.53

GST (18%): ₹ 6,073.475

Total Price: ₹ 39,815.005

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

application(s)

clinical testing

format

neat

storage temp.

−20°C

SMILES string

O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1

InChI

1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

InChI key

IOIZWEJGGCZDOL-RQDYSCIWSA-N

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Description

  • General description: 7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.[1]
  • Application: C4 may be used as a reference standard for the determination of C4 in:Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI)[2] as well as LC-MS.[1]Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection.[3]Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.[4]
  • Biochem/physiol Actions: 7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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analytical standard

Quality Level:
100

Assay:
≥95.0% (HPLC)

application(s):
clinical testing

format:
neat

storage temp.:
−20°C

SMILES string:
O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1

InChI:
1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

InChI key:
IOIZWEJGGCZDOL-RQDYSCIWSA-N

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