Description

• Application: L-Cystine has been used as a supplement in astroglial-conditioned media to culture cerebral astroglia.[1] It has been used in several techniques, such as HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry (UHPLC-MS/MS), to differentiate BMAA (β-N-methylamino-L-alanine), the cyanobacterial neurotoxin, from other diamino acids.[2]L-Cystine has been used as a supplement in oocyte culture media to improve oocyte maturation and parthenogenesis of embryonic development.[3]
• Biochem/physiol Actions: Cystinuria is characterized with renal transport and excretion of L-Cystine.[4] Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine.[5] Reduced availability of cysteine or cystine, influences leukocyte metabolism.[6] L-Cystine is necessary for oxygen production and LDL (low density lipoprotein) modification by arterial smooth muscle cells.