Description

• Application: 2′,3′-Dideoxycytidine is used:as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination methodas a nucleoside reverse transcriptase inhibitor (NRTI) to study its effects on the development of mechanical allodynia in aging mice[1]as a mitochondrial DNA (mtDNA) replication inhibitor to inhibit the activation of cGAS-STING pathway and study its effects on signaling protein-stimulator of interferon genes (STING), cyclic GMP-AMP synthase (cGAS), and phospho-interferon regulator factor 3 (p-IRF3) expression in mouse hippocampal and microglial cells[2]as an NRTI inhibitor to study its effects on the drug induced-mitochondrial toxicity in Caenorhabditis elegans[3]
• Biochem/physiol Actions: 2′,3′-Dideoxycytidine (ddC), is an ionic compound and a nucleoside analog.[4] [5]It acts as a nucleoside reverse transcriptase inhibitor and exhibits therapeutic effects against human immunodeficiency virus (HIV) infection.[5] 2′,3′-Dideoxycytidine possesses anti-adenovirus activity and inhibits the adenovirus polymerase.[6]