Metabolites in human plasma

Description

• General description: SRM 1950 is designed to represent “normal” human plasma.It was developed in a collaboration between the National Institute of Standards and Technology (NIST) and the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Analyses for value assignment were performed by NIST and the Centers for Disease Control and Prevention (CDC) (Atlanta, GA). All certified and reference values, with the exception of vitamin D-binding protein, are based on the agreement between the results from NIST methods and from the CDC, where available. The reference value for vitamin D-binding protein is based on the agreement between the results from a NIST method and the University of Washington method. SRM 1950 _SDSSRM 1950_CERT
• Application: This Standard Reference Material (SRM) is intended primarily for the validation of methods for determining metabolites such as fatty acids, electrolytes, vitamins, hormones, and amino acids in human plasma and similar materials. This SRM can also be used for comparison of measurement technologies used in metabolomic studies and for quality assurance when assigning values to in-house reference materials.The standard has been used:to determine the accuracy of vitamin D in human serum by liquid chromatography-tandem mass spectrometry (LC-MS/MS)[1]to determine the unbound free fatty acid profile of human plasma[2]to determine the C24 bile acids in human serum and urine samples by liquid chromatography-mass spectrometry (LC-MS) method[3]
• Features and Benefits: A unit of SRM 1950 consists of five vials, each containing approximately 1.0 mL of plasmaThe associated uncertainties are expressed at the 95 %level of confidenceInformation on product description, disposal, and transportation is available in the accompanying MSDSThe enclosed NIST certificate contains details on the expiry date, warning to users, instructions for right storage and use, preparation, and analysis of the RM
• Legal Information: NIST is a registered trademark of National Institute of Standards and Technology