PHR1185
Amlodipine besylate
Pharmaceutical Secondary Standard; Certified Reference Material
Manufacturer: Supelco
CAS Number: 111470-99-6
Synonym(S): (4R, S)-3-Ethyl-5-methyl 2-(2-amino-ethoxy-methyl)-4-(2-chlorophenyl)-1,4-dihydroxy-6-methyl pyridine-3,5-dicarboxylate monobenzene sulphonate, 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 G | PHR1185-1-G | In Stock | ₹ 10,132.20 |
PHR1185 - 1 G
In Stock
Quantity
1
Base Price: ₹ 10,132.20
GST (18%): ₹ 1,823.796
Total Price: ₹ 11,955.996
grade
certified reference materialpharmaceutical secondary standard
Quality Level
300
Agency
traceable to Ph. Eur. Y0000049traceable to USP 1029501
API family
amlodipine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitablegas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
Other Options
Description
- General description: Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amlodipine besylate is a calcium channel blocker, which inhibits the trans membrane influx of calcium ions into vascular smooth muscles and cardiac muscle. It belongs to the dihydropyridine family. It is used in combination with atorvastatin calcium to treat vasospastic angina, chronic stable angina, hypertension, in elevated serum triglyceride levels, primary dysbetalipoproteinemia.[1]
- Application: Amlodipine besylate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2][3] using different chromatography techniques[1][2] and spectrophotometric technique.[3]
- Biochem/physiol Actions: Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
- Analysis Note: These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
- Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
- Footnote: To see an example of a Certificate of Analysis for this material enter LRAC0717 in the slot below. This is an example certificate only and may not be the lot that you receive.
- Recommended products: Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
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grade: certified reference materialpharmaceutical secondary standard
Quality Level: 300
Agency: traceable to Ph. Eur. Y0000049traceable to USP 1029501
API family: amlodipine
CofA: current certificate can be downloaded
technique(s): HPLC: suitablegas chromatography (GC): suitable
application(s): pharmaceutical (small molecule)
format: neat
storage temp.: 2-8°C
SMILES string: OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
grade:
certified reference materialpharmaceutical secondary standard
Quality Level:
300
Agency:
traceable to Ph. Eur. Y0000049traceable to USP 1029501
API family:
amlodipine
CofA:
current certificate can be downloaded
technique(s):
HPLC: suitablegas chromatography (GC): suitable
application(s):
pharmaceutical (small molecule)
format:
neat
storage temp.:
2-8°C
SMILES string:
OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
grade: certified reference materialpharmaceutical secondary standard
Quality Level: 300
Agency: traceable to Ph. Eur. T1850000traceable to USP 1674004
API family: tretinoin
CofA: current certificate can be downloaded
technique(s): HPLC: suitablegas chromatography (GC): suitable
application(s): food and beverages
format: neat
storage temp.: __
SMILES string: __
grade:
certified reference materialpharmaceutical secondary standard
Quality Level:
300
Agency:
traceable to Ph. Eur. T1850000traceable to USP 1674004
API family:
tretinoin
CofA:
current certificate can be downloaded
technique(s):
HPLC: suitablegas chromatography (GC): suitable
application(s):
food and beverages
format:
neat
storage temp.:
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SMILES string:
__
grade: certified reference materialpharmaceutical secondary standard
Quality Level: 300
Agency: traceable to Ph. Eur. I0800000traceable to USP 1353500
API family: isotretinoin
CofA: current certificate can be downloaded
technique(s): HPLC: suitablegas chromatography (GC): suitable
application(s): pharmaceutical (small molecule)
format: neat
storage temp.: -10 to -25°C
SMILES string: __
grade:
certified reference materialpharmaceutical secondary standard
Quality Level:
300
Agency:
traceable to Ph. Eur. I0800000traceable to USP 1353500
API family:
isotretinoin
CofA:
current certificate can be downloaded
technique(s):
HPLC: suitablegas chromatography (GC): suitable
application(s):
pharmaceutical (small molecule)
format:
neat
storage temp.:
-10 to -25°C
SMILES string:
__
grade: certified reference materialpharmaceutical secondary standard
Quality Level: 300
Agency: traceable to USP 1464001
API family: nitrofurantoin
CofA: current certificate can be downloaded
technique(s): HPLC: suitablegas chromatography (GC): suitable
application(s): cleaning productscosmeticsfood and beveragespersonal carepharmaceutical (small molecule)
format: neat
storage temp.: 2-30°C
SMILES string: [O-][N+](=O)c1ccc(\C=N\N2CC(=O)NC2=O)o1
grade:
certified reference materialpharmaceutical secondary standard
Quality Level:
300
Agency:
traceable to USP 1464001
API family:
nitrofurantoin
CofA:
current certificate can be downloaded
technique(s):
HPLC: suitablegas chromatography (GC): suitable
application(s):
cleaning productscosmeticsfood and beveragespersonal carepharmaceutical (small molecule)
format:
neat
storage temp.:
2-30°C
SMILES string:
[O-][N+](=O)c1ccc(\C=N\N2CC(=O)NC2=O)o1