Description

• General description: Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Natamycin is a major drug that is utilized in the treatment of fungal keratitis. It is, by far, the only available approved antifungal drug for the said purpose by the U.S. Food and Drug Administration.[1]
• Application: Natamycin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high-performance liquid chromatography coupled with tandem mass spectrometry (LC−MS/MS).[1]
• Biochem/physiol Actions: An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane
• Analysis Note: These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
• Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
• Footnote: To see an example of a Certificate of Analysis for this material enter LRAC2803 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.