Description

• General description: Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
• Application: Pharmacokinetic Study of Alpha-Hydroxytriazolam: Research involving the urinary excretion of alpha-hydroxytriazolam after a single dose of Halcion provides insights into the metabolic pathways and elimination characteristics of this benzodiazepine derivative. Using α-Hydroxytriazolam-d₄ as an internal standard in mass spectrometry enhances the accuracy of such studies, which is critical for understanding the drug′s behavior in the human body and for developing therapeutic guidelines (Lin et al., 2005).Confirmation of Urinary Benzodiazepine Metabolites: A study that utilizes gas chromatography-mass spectrometry (GC-MS) to confirm the presence of urinary benzodiazepine metabolites, including α-Hydroxytriazolam, emphasizes the role of α-Hydroxytriazolam-d₄ as a vital analytical standard. This research aids in forensic toxicology and clinical diagnostics by providing robust methodologies for the detection and quantification of benzodiazepines in biological samples (Meatherall, 1994).
• Analysis Note: These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
• Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
• Footnote: To see an example of a Certificate of Analysis for this material enter LRAB3994 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.