Description

• Application: Resveratrol has been used:in entrapment experiment[1]to study its neuroprotective effect on retinal neuronal cell death mediated by diabetes-induced activation of Ca2+/calmodulin-dependent protein kinase II[2]as a standard in the assessment of stilbene content in grapevine leaf by in vivo fluorometry[3]
• Biochem/physiol Actions: Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-g-activated receptor coactivator-1a (PGC-1a) and FOXO (forkhead box) activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. Resveratrol has antiviral action against Herpes simplex virus-1 (HSV1) and HSV2. It also exhibits antitumor and phytoestrogenic biological activities.[4] Resveratrol is known to prolong life in many species by mediating several physiological events.[5]
• Preparation Note: Soluble in ethanol, DMSO, and acetone. Only very slightly soluble in water (3 mg/100 mL).