Description

• General description: This internal standard and Certified Spiking Solution® is suitable for quantitation of free and total T4 serum levels by LC-MS/MS for determination of hyper- or hypothyroidism and monitoring treatment with synthetic thyroid hormones.L-Thyroxine-13C6 is an isotopically labeled form of the tyrosine-based thyroid hormone, thyroxine (T4). Thyroxine is secreted by the thyroid gland and is involved in different biological processes, such as growth, neurodevelopment, carbohydrate & oxygen metabolism, and protein synthesis
• Application: The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:Combination of hollow fiber-liquid-phase microextraction (HF-LPME) based sample preparation and liquid chromatography-tandem mass spectrometric (LC-MS/MS) determination of total thyroxine in serum samplesDevelopment of an LC-MS/MS method for the multi-residue analysis of melatonin, cortisol, triiodothyronine, thyroxine, and testosterone in rat serum samples following their dual liquid-liquid extractionSimultaneous determination of thyroxine by an isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method from human serum samplesEstimation of thyroxine (T4) and triiodothyronine (T3) in rat cardiac tissue samples by a high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method following their derivatizationEstablishing and validating an LC-MS/MS-based method for the quantification of endogenous thyroid hormones, T4 and two of its T3 isomers, in tissue samples obtained from lamprey, following the enzymatic digestion and protein precipitation of the samples
• Features and Benefits: Fully characterized under ISO/IEC 17025 and ISO 17034 accreditationAccompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability Rigorously tested through real-time stability studies to ensure accuracy and shelf life Gravimetrically prepared using qualified precision balances to ensure minimal uncertaintyFlame sealed under argon into ampoules for long-term shelf lifeOffered in a convenient, DEA-exempt format to improve laboratory efficiency
• Legal Information: CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany