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50-112-9131

CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-112-9131-Each-of-1 In Stock ₹ 43,165.00

50-112-9131 - Each of 1

₹ 43,165.00

In Stock

Quantity

1

Base Price: ₹ 43,165.00

GST (18%): ₹ 7,769.70

Total Price: ₹ 50,934.70

Antigen

CD266 (TWEAK Receptor)

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

Q9CR75, Q9NP84

Gene Symbols

TNFRSF12A

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

27279, 51330

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot

Clone

ITEM-4

Conjugate

Functional Grade

Gene

TNFRSF12A

Gene Alias

AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14

Host Species

Mouse

Quantity

500 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG2b κ

Description

  • Description: The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein)
  • Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region
  • Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis
  • TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1
  • Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs
  • Fn14 mRNA expression has been identified during liver regeneration
  • It has been reported that ITEM-4 cross-reacts with mouse Fn14
  • In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line
  • The ITEM-4 antibody has been show to have blocking function
  • Applications Reported: This ITEM-4 antibody has been reported for use in flow cytometric analysis, western blotting, and immunohistochemical staining of frozen tissue sections
  • Applications Tested: This ITEM-4 antibody has been tested by flow cytometry of CD266 transfected cell lines
  • This can be used at less than or equal to 1 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines
  • Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library
  • TweakR is a small protein belonging to TNF receptor super family
  • TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3
  • TweakR mRNA is upregulated during tissue regeneration in the aorta and liver
  • It may also play a role in vascular cell migration and angiogenesis.