50-113-8153
CD19 Monoclonal Antibody (6D5), Qdot™ 655, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-8153-Each-of-1 | In Stock | ₹ 49,306.00 |
50-113-8153 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,306.00
GST (18%): ₹ 8,875.08
Total Price: ₹ 58,181.08
Antigen
CD19
Classification
Monoclonal
Conjugate
Qdot 655
Gene
Cd19
Gene Alias
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12478
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry
Clone
6D5
Formulation
0.05M borate with 1M betaine and 0.05% sodium azide; pH 8.3
Gene Accession No.
P25918
Gene Symbols
Cd19
Immunogen
mouse CD19 antigen
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
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Description
- CD19 is a member of the immunoglobulin superfamily and has two Ig like domains
- The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains
- CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage
- Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen
- The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias
- Lymphocytes proliferate and differentiate in response to various concentrations of different antigens
- The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors
- CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation
- Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge
- Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.