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50-147-05

IL-6 Monoclonal Antibody (MP5-20F3), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-147-05-Each-of-1 In Stock ₹ 31,773.00

50-147-05 - Each of 1

₹ 31,773.00

In Stock

Quantity

1

Base Price: ₹ 31,773.00

GST (18%): ₹ 5,719.14

Total Price: ₹ 37,492.14

Antigen

IL-6

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

P08505

Gene Symbols

Il6

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

16193

Content And Storage

4° C

Form

Liquid

Applications

Functional Assay, Immunostaining, Neutralization

Clone

MP5-20F3

Conjugate

Functional Grade

Gene

Il6

Gene Alias

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

Host Species

Rat

Quantity

500 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG1 κ

Description

  • Description: The MP5-20F3 antibody reacts with mouse interleukin-6 (IL-6)
  • The MP5-20F3 antibody is a neutralizing antibody
  • Mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a 21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells
  • Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6
  • This pleiotrophic cytokine influences the antigen-specific immune response, inflammatory response, and the development of neurons, and is a major mediator of the acute phase reaction
  • Applications Reported: This MP5-20F3 antibody has been reported for use in cytokine neutralization, ELISA capture antibody, and ELISPOT capture antibody
  • Applications Tested: The Functional Grade Purified MP5-20F3 antibody has been tested by LAL assay to verify low endotoxin levels, by ELISA, and in bioassay for neutralization of mouse IL-6 bioactivity
  • The MP5-20F3 antibody at 0.03 μg/mL has been found to inhibit by 50% the biological effects of 0.01 ng/mL mouse IL-6 in an B9 cell proliferation assay
  • Detailed information and protocols about can be found in the BestProtocols™ section
  • The MP5-20F3 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse interleukin-6 (IL-6) in combination with the biotinylated MP5-32C11 (cat
  • 13-7062) antibody for detection and recombit mouse IL-6 (cat
  • IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells
  • The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections
  • The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha
  • The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis
  • Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2)
  • Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.