IL-6 Monoclonal Antibody (MQ2-13A5), Functional Grade, eBioscience™, Invitrogen™

Description

• Description: The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21-28 kDa cytokine secreted by a variety of cell types
• Applications Reported: This MQ2-13A5 antibody has been reported for use in cytokine neutralization, ELISPOT, and ELISA capture
• Applications Tested: The MQ2-13A5 antibody has been tested for neutralizing IL-6 binding and biological activity
• Storage and handling: Use in a sterile environment
• Filtration: 0.2 μm post-manufacturing filtered
• Purity: Greater than 90%, as determined by SDS-PAGE
• Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
• Aggregation: Less than 10%, as determined by HPLC
• IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells
• The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections
• The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha
• The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis
• Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2)
• Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.