Phospho-BRCA1 (Ser1423) Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla and Chimpanzee BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex)
• BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex
• The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination
• Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers
• Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene
• Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described
• A related pseudogene, which is also located on chromosome 17, has been identified.