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7192835

IRF4 Monoclonal Antibody (3E4), Alexa Fluor™ 700, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

IRF4

Concentration

0.2 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP

Gene Symbols

IRF4

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

IRF4

Clone

3E4

Applications

Flow Cytometry

Conjugate

Alexa Fluor 700

Host Species

Rat

Target Species

Human, Mouse

Gene Accession No.

Q15306, Q64287

Gene ID (Entrez)

16364, 3662

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain
  • The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes
  • IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems
  • A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma
  • Alternatively spliced transcript variants have been found.