CD15 Mouse anti-Human, Unlabeled, Clone: W6D3, BD

Description

• The W6D3 monoclonal antibody specifically binds to 3-fucosyl-N-acetyllactosamine (3-FAL), a 220 kDa carbohydrate structure, also called X-hapten
• 3-FAL is expressed on >95% of granulocytes, including neutrophils and eosinophils, and on monocytes to a varying degree, but not on lymphocytes or basophils
• CD15 plays a role in mediating phagocytosis, bactericidal activity and chemotaxis
• Most CD15 antibodies are IgM isotype; clone W6D3 is a mouse IgG1 isotype
• In comparison studies with clone HI98, a known CD15 antibody, clone W6D3 shows brighter fluorescence staining and its binding can be blocked by clone HI98
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.