Reacts with CD31, also known as platelet endothelial cell adhesion molecule - 1 (PECAM-1), a sigle chain, type I transmembrane protein of approximately 130 - 140 kDa
CD31 is a member of the immunoglobulin supergene family, its extracellular region is composed of 574 aminoacids and contains six C2-type Ig domains, its intracellular region is composed of 118 residues
CD31 (PECAM-1) is expressed on endothelial cells, platelets, monocytes, neutrophils and NK cells
It has also been observed on subsets of T cells, but not on circulating B cells
It has been implicated in a number of cellular phenomena, including vascular wound healing, angiogenesis, and transendothelial migration of leukocytes and platelet aggregation in inflammatory responses.