CD106 Rat anti-Mouse, Alexa Fluor 647, Clone: 429 (MVCAM.A), BD

Description

• The 429 monoclonal antibody specifically binds to both the long (∽110 kDa) transmembrane-spanning form and the truncated (∽47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106)
• CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells
• Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions
• CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines
• VCAM-1 is a counter-receptor for VLA-4 ( α 4β 1 integrin) and LPAM-1 ( α 4β 7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions
• Source of the immunogen was the mouse preadipose cell line PA6.