Factor XIII A Ab-2 Rabbit Polyclonal Antibody, Epredia™

Description

• Factor XIII A Ab-2 detects Factor XIII in both reduced and non-reduced forms
• It does not react with human Factor XIII B-chain or human Factor XII
• Factor XIII is a Β-globulin found in plasma and is composed of two subunits
• Factor XIII-A is the catalytic subunit and is a dimmer of M.W
• 160 kDa
• Factor XIII is present in plasma as an α2Β2 heterodimer (M.W
• 320 kDa); whereas in platelets, only the α2 unit exists
• Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors
• It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system
• Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans
• Host Species: Rabbit Isotype: IgG Species Reactivity: Human
• Others not known
• Epitope: Not determined Immunogen: Recombinant protein corresponding to A-subunit of coagulation Factor XIII Molecular Weight: 160 kDa (unreduced dimer); 80 kDa (reduced monomer) Positive Control: Human recombinant Factor XIII A-subunit; Capillary hemangioma, dermatofibroma and placenta Cellular Localization: Cytoplasmic and nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Note: USA: RUO; Int'l: RUO