Description

• General description: Creatinine is excreted at fairly constant rates in the absence of renal disease and commonly used as benchmark in urinary biomarker analysis. Serum creatinine levels are useful indicators of renal function and have been implicated in diabetes, cardiovascular and circulatory diseases. This stable-labeled internal standard is suitable for quantification of creatinine levels by LC/MS or GC/MS for applications in clinical diagnostic, urine drug testing or forensic analysis.
• Application: Quantification in biofluids: Creatinine-D₃ is crucial for the quantification of gut microbiota dysbiosis-related organic acids in human urine. This study demonstrates the utility of LC-MS/MS in assessing microbiome health and its impact on metabolic pathways, highlighting the compound′s role in biochemical research and clinical diagnostics (Lee et al., 2022).Urine creatinine measurement: The development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for measuring creatinine in human urine showcase Creatinine-D₃ as a vital standard. This method is pivotal for ensuring accurate and reliable results in clinical and biochemical assays, particularly in kidney function testing (Fraselle et al., 2015).Enhanced detection techniques: Creatinine-D₃ is used in innovative analytical techniques like reactive-thermal desorption-extractive electrospray-ion mobility-tandem mass spectrometry. This method allows for the direct determination of urinary creatinine, providing faster, more sensitive analyses suitable for rapid clinical assessments (Devenport et al., 2014).Tracking creatine metabolism: In research exploring the metabolism of ingested creatine, Creatinine-D₃ is utilized to trace its metabolic fate in urine, plasma, and red blood cells. This application is crucial for studies on dietary supplements and their impact on health, particularly in sports science and nutrition (MacNeil et al., 2005).
• Legal Information: CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany