C6891
5-Chloro-2′-deoxyuridine
thymidine analog
Manufacturer: Sigma Aldrich
CAS Number: 50-90-8
Synonym(S): CldU
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | C6891-100-MG | In Stock | ₹ 10,695.10 |
C6891 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 10,695.10
GST (18%): ₹ 1,925.118
Total Price: ₹ 12,620.218
Quality Level
100
Assay
≥98% (HPLC)
form
powder
solubility
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
NJCXGFKPQSFZIB-RRKCRQDMSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences 5-Chloro-2′-deoxyuridine | 50-90-8 | MFCD00006531 | 100 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 10,795.96 | |
 | Medchemexpress LLC HY-112669 100mg Medchemexpress, 5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine;CldU CAS:50-90-8 Purity:98% | Medchemexpress LLC | ₹ 7,187.04 | |
 | 5-Chloro-2'-deoxyuridine | ChemScene | ₹ 4,791.36 - ₹ 64,768.92 | |
 | 50-90-8 | Uridine, 5-chloro-2'-deoxy- | A2B Chem | ₹ 3,080.16 - ₹ 70,758.12 |
Description
- Application: 5-Chloro-2′-deoxyuridine has been used to:study cell cycle dynamics by immunohistochemical analysis and double S-phase labeling using animal models[1]analyze cell cycle length using an animal model[2]label HEK293T cells for molecular combing assay[3]
- Biochem/physiol Actions: DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination.[4] CldU is a potent mutagen, clastogen, and toxicant.[5] It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest.[4] CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs.[5] 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
solubility: 1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp.: −20°C
SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI: 1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key: NJCXGFKPQSFZIB-RRKCRQDMSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
solubility:
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp.:
−20°C
SMILES string:
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI:
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key:
NJCXGFKPQSFZIB-RRKCRQDMSA-N
Quality Level: 200
Assay: __
form: powder or crystals
solubility: soluble (slightly soluble in water, practically insoluble in methanol, ethanol)
storage temp.: __
SMILES string: N[C@@H](C(=O)N[C@H]1[C@H]2SCC(Cl)=C(N2C1=O)C(O)=O)c3ccccc3
InChI: 1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
InChI key: QYIYFLOTGYLRGG-GPCCPHFNSA-N
Quality Level:
200
Assay:
__
form:
powder or crystals
solubility:
soluble (slightly soluble in water, practically insoluble in methanol, ethanol)
storage temp.:
__
SMILES string:
N[C@@H](C(=O)N[C@H]1[C@H]2SCC(Cl)=C(N2C1=O)C(O)=O)c3ccccc3
InChI:
1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
InChI key:
QYIYFLOTGYLRGG-GPCCPHFNSA-N
Quality Level: 300
Assay: ≥98% (PAGE)
form: essentially salt-free, lyophilized powder
solubility: __
storage temp.: −20°C
SMILES string: __
InChI: 1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key: BECPQYXYKAMYBN-UHFFFAOYSA-N
Quality Level:
300
Assay:
≥98% (PAGE)
form:
essentially salt-free, lyophilized powder
solubility:
__
storage temp.:
−20°C
SMILES string:
__
InChI:
1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key:
BECPQYXYKAMYBN-UHFFFAOYSA-N
Quality Level: __
Assay: __
form: __
solubility: __
storage temp.: __
SMILES string: __
InChI: __
InChI key: __
Quality Level:
__
Assay:
__
form:
__
solubility:
__
storage temp.:
__
SMILES string:
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InChI:
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InChI key:
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