5545595

Tocris Bioscience™ RQ 00203078

Potent and selective TRPM8 antagonist; orally active

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Description

RQ 00203078

Molecular Weight (g/mol)

554.85

Product Type

RQ 00203078

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Description

  • Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively)
  • Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1
  • Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro
  • Also attenuates icilin -induced wet dog shakes in rats
  • Orally active.

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