Thermo Scientific Chemicals Endothelin-1, Human

Description

• Endothelin 1 has been used for coating wells in polystyrene ELISA plates
• Potent agonist for ETA and ETB endothelia receptors
• Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF
• This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio
• Some documentation and label information may refer to the legacy brand
• The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals
• General Description • Endothelin-1 is a peptide that belongs to the endothelin family, with potent vasoconstrictor activity that is synthesized and secreted by activated endothelial cells
• It is considered a marker for activated or dysfunctional endothelial cells Application • Endothelin-1 acts as a modulator of vasomotor tone, cell proliferation, and hormone production
• • In the laboratory, endothelin-1 has been used to coat wells in polystyrene ELISA plates • It is a potent agonist for ETA and ETB endothelial receptors
• Therefore, after receptor activation, this compound induces the production of hypoxia-inducible factor 1α and, thus, the production of VEGF • It has been used to study the production and detection of H2O2 and production of NO in the presence of endothelin-1 • It has been utilized in studies to understand the effects of endothelin-1 on protein kinase C activity in human umbilical vein endothelial cells (HUVEC)