Human Lass6, Synthetic Peptide, Invitrogen™

Description

• Lass6 Synthetic Peptide, PEP-12929, from Invitrogen
• Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family
• Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis
• However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation
• May be involved in sphingolipid synthesis or its regulation
• Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1
• Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane
• Glycosylation on Asn-18 is not necessary for function
• Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain
• Lass6 displays highest homology to LASS5
• The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb
• Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved
• LASS6 was shown to be broadly expressed in a wide range of tissues
• Recent data suggested a role in cancer differentiation and early embryonic development
• A suggested positive control for this product is kidney, liver, brain, heart, placenta or lung lysate.