PV4387
Thermo Scientific™ Fluorescein-D22 Coactivator Peptide, 100 μM
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PV4387-Each-of-1 | In Stock | ₹ 93,984.00 |
PV4387 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 93,984.00
GST (18%): ₹ 16,917.12
Total Price: ₹ 1,10,901.12
Content And Storage
LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100 μM solutions in peptide-appropriate buffers. Store peptides at -20°C.
Label Type
Classic Dyes
Quantity
1 mL
Shipping Condition
Dry Ice
Related Products
Description
- LanthaScreen™ fluorescent nuclear receptor coregulator peptides contain known interaction motifs and are labeled with fluorescein
- These peptides are matched and validated to complement the LanthaScreen™ TR-FRET Nuclear Receptor Coregulator Assays
- Assays developed using these reagents enable primary or secondary screening of nuclear receptor agonists and/or antagonists
- How they work Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes
- TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide
- In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein
- An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide (Figure 1)
- The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio (Figure 2).
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Content And Storage: LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100 μM solutions in peptide-appropriate buffers. Store peptides at -20°C.
Label Type: Classic Dyes
Quantity: 1 mL
Shipping Condition: Dry Ice
Content And Storage:
LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100 μM solutions in peptide-appropriate buffers. Store peptides at -20°C.
Label Type:
Classic Dyes
Quantity:
1 mL
Shipping Condition:
Dry Ice
Content And Storage: Phosphate Sensor is supplied as a 500 μM solution in 10 mM Tris (pH 7.6) and 50 mM NaCl. Store product at -80°C.
Label Type: __
Quantity: 10 nmol
Shipping Condition: Dry Ice
Content And Storage:
Phosphate Sensor is supplied as a 500 μM solution in 10 mM Tris (pH 7.6) and 50 mM NaCl. Store product at -80°C.
Label Type:
__
Quantity:
10 nmol
Shipping Condition:
Dry Ice
Content And Storage: Phosphate Sensor is supplied as a 500 μM solution in 10 mM Tris (pH 7.6) and 50 mM NaCl. Store product at -80°C.
Label Type: __
Quantity: 100 nmol
Shipping Condition: Dry Ice
Content And Storage:
Phosphate Sensor is supplied as a 500 μM solution in 10 mM Tris (pH 7.6) and 50 mM NaCl. Store product at -80°C.
Label Type:
__
Quantity:
100 nmol
Shipping Condition:
Dry Ice
Content And Storage: TR-FRET Coregulator Buffer B may be shipped frozen or at room temperature.Store at room temperature (20°C to 30°C).
Label Type: __
Quantity: 25 mL
Shipping Condition: Approved for shipment at Room Temperature or on Wet or Dry Ice
Content And Storage:
TR-FRET Coregulator Buffer B may be shipped frozen or at room temperature.Store at room temperature (20°C to 30°C).
Label Type:
__
Quantity:
25 mL
Shipping Condition:
Approved for shipment at Room Temperature or on Wet or Dry Ice