Invitrogen™ Human Activated Protein C, Native Protein

Description

• Activated Protein C (human) Native Protein, RP-43095, from Invitrogen
• Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex
• Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII
• Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains
• The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation
• The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3ug/mL
• Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis
• RP-43095 contains native human Activated Protein C protein
• RP-43095 may be used as a positive control in many immunological assays
• The RP-43095 protein molecular weight is ∽56.2 kDa
• The product is of human blood/plasma origin
• Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests
• This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!