Human Neutrophil elastase, Native Protein, Invitrogen™

Description

• Neutrophil Elastase (human) Native Protein, RP-77526, from Invitrogen
• Leukocyte elastase is one of several hydrolytic enzymes contained in the azurophil granules of human neutrophils exhibiting a relative molecular weight of 29.5 kDa
• The enzyme differs from pancreatic elastase in specificity on synthetic substates and in inhibitor sensitivity
• Leukozyte elastase shows only moderate sequence homology with pancreatic elastase
• It has a very narrow specificity, cleaving Val-X bonds preferentially, and Ala-X links to a lesser extent
• It has been shown to degrade elastin, cartilage proteoglycans, several collagens and fibronectin
• Physiologically, it is involved in the degradation of foreign materials ingested during phagocytosis
• Damage to connective tissue caused by leakage of enzymes is normally limited by proteinase inhibitors
• It has been suggested that insufficiant levels of these inhibitors leads to pulmonary emphysema, and elastase in particular has been implicated in abnormal lung connective tissue turnover
• RP-77526 is native Neutrophil Elastase protein purified from whole human blood samples
• RP-77526 may be used as a control with corresponding anti-Neutrophil Elastase antibodies
• RP-77526 is prepared from whole human blood shown to be non-reactive for HbsAG, anti HCV, anti-HBc, and negative for anti-HIV1 2 by FDA approved tests.