Polysuccinimide

Description

• General description: Polysuccinimide (PSI), commonly synthesized through thermal polymerization, is a polyimide precursor for the production of such biocompatible and degradable polymers namely polyaspartic acid and various polyaspartamides. Polyaspartic acid is produced by hydrolysis of PSI under alkaline condition while polyaspartamide is produced by ring opening of PSI using a nucleophilic reagent. The presence of amide linkages in these polymers gives them peptide-like structures which is prone to hydrolysis and subsequent degradation. These derivatives could be potential substitutes for different polyamino acids in many medical applications.
• Application: Polysuccinimide (PSI) has been used for a variety of applications including: As a nanocarrier or microcarrier delivery vehicle in pharmaceutical, cosmetic, and agriculture (agrochemical) fields As electrospun fibers, films, meshes or mats for wound healing applications As nanofibers for electronic and biosensor applications As a sustainable and environmentally friendly alternative to non-degradable polymers
• Features and Benefits: Biodegradable by hydrolysis allowing for sustained and controlled delivery High swelling ratio with superabsorbent properties Water soluble Peptide-like and biocompatible