Dehydrocostus lactone
phyproof® Reference Substance
Manufacturer: Sigma Aldrich
CAS Number: 477-43-0
Synonym(S): (−)-Dehydrocostus lactone; Dehydrocostus lactone; Epiligulyl oxide, (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one, Dehydro-costus lactone (6CI,7CI), Dehydrocostuslactone, Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone, [3aS-(3aα,6aα,9aα,9bβ)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 MG | PHL89624-10-MG | In Stock | ₹ 47,662.48 |
PHL89624 - 10 MG
In Stock
Quantity
1
Base Price: ₹ 47,662.48
GST (18%): ₹ 8,579.246
Total Price: ₹ 56,241.726
grade
primary reference standard
product line
phyproof® Reference Substance
Assay
≥95.0% (HPLC)
form
solid
manufacturer/tradename
PhytoLab
storage temp.
−20°C
SMILES string
C=C1CC[C@@]2([H])C(CC[C@@H]3[C@H](OC(C3=C)=O)[C@]21[H])=C
InChI
1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChI key
NETSQGRTUNRXEO-XUXIUFHCSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Dehydrocostus lactone | Supelco | ₹ 10,034.78 |
Related Products
Description
- General description: This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
- Biochem/physiol Actions: Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine receptor signaling. The SOCS family include eight members SOCS-1 to SOCS-7 and CIS. Dehydrocostuslactone (DHE) is a sesquiterpene lactone extracted from Saussurea lappa and Aucklandia lappa. The compound possess antifungal and antimycobacterial activity and exhibit a cytotoxic effect against HepG2, OVCAR-3, and HeLa cell lines. DHE inhibits cell proliferation not only in early-stage breast cancer MCF-7 but also in more advanced stage MDA-MB-231 cancer cells, without significant effect on H184B5F5/M10 normal mammary epithelial cells. The inhibition of breast cancer cells proliferation occurs through cell cycle blockade and apoptosis. DHE inhibits cell cycle progression and cell death through SOCS-1 and SOCS-3.
- Legal Information: phyproof is a registered trademark of PhytoLab GmbH & Co. KG
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
Hazard Classifications
Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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grade: primary reference standard
product line: phyproof® Reference Substance
Assay: ≥95.0% (HPLC)
form: solid
manufacturer/tradename: PhytoLab
storage temp.: −20°C
SMILES string: C=C1CC[C@@]2([H])C(CC[C@@H]3[C@H](OC(C3=C)=O)[C@]21[H])=C
InChI: 1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChI key: NETSQGRTUNRXEO-XUXIUFHCSA-N
grade: primary reference standard
product line: phyproof® Reference Substance
Assay: ≥90.0% (HPLC)
form: __
manufacturer/tradename: PhytoLab
storage temp.: −20°C
SMILES string: [Cl-].Oc1cc(O)c2cc(O)c([o+]c2c1)-c3cc(O)c(O)c(O)c3
InChI: 1S/C15H10O7.ClH/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6;/h1-5H,(H5-,16,17,18,19,20,21);1H
InChI key: FFNDMZIBVDSQFI-UHFFFAOYSA-N
grade: primary reference standard
product line: phyproof® Reference Substance
Assay: ≥95.0% (HPLC)
form: __
manufacturer/tradename: PhytoLab
storage temp.: −20°C
SMILES string: __
InChI: 1S/C27H30O17.ClH/c28-6-16-19(34)21(36)23(38)26(43-16)41-14-4-9(30)3-13-10(14)5-15(25(40-13)8-1-11(31)18(33)12(32)2-8)42-27-24(39)22(37)20(35)17(7-29)44-27;/h1-5,16-17,19-24,26-29,34-39H,6-7H2,(H3-,30,31,32,33);1H
InChI key: HKHQPWJHAKAMGC-UHFFFAOYSA-N
