Cyclosporine

Name: Cyclosporine | Supelco | Chemikart
Brand: Chemikart

Pharmaceutical Secondary Standard; Certified Reference Material

Manufacturer: Supelco

CAS Number: 59865-13-3

Synonym(S): Cyclosporin A, Antibiotic S 7481F1, Cyclosporine

Select a Size

Pack Size	SKU	Availability	Price
500 MG	PHR1092-500-MG	In Stock	₹ 18,175.18

PHR1092 - 500 MG

₹ 18,175.18

In Stock

Quantity

Base Price: ₹ 18,175.18

GST (18%): ₹ 3,271.532

Total Price: ₹ 21,446.712

grade

certified reference materialpharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. C2163000traceable to USP 1158504

API family

cyclosporine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitablegas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

Other Options

Product Name	Manufacturer	Price Range
Sigma Aldrich Fine Chemicals Biosciences Ciclosporin European Pharmacopoeia (EP) Reference Standard \| 59865-13-3 \| MFCD00274558 \|	Sigma Aldrich Fine Chemicals Biosciences	₹ 23,582.90
Cyclosporine Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™	MilliporeSigma Supelco	₹ 23,143.98
Sigma Aldrich Fine Chemicals Biosciences Cyclosporin A \| 59865-13-3 \| MFCD00274558 \| 5mg	Sigma Aldrich Fine Chemicals Biosciences	₹ 31,652.92
Sigma Aldrich Fine Chemicals Biosciences Cyclosporin A, Ready Made Solution 1 mg/mL in DMSO (0.2 μm-filtered) \| 59865-13-3 \| 1ml	Sigma Aldrich Fine Chemicals Biosciences	₹ 17,189.00
eMolecules Medchem Express / Cyclosporin A / 100mg / 446273016 / HY-B0579 / / 59865-13-3 / MFCD00274558 / 1202.635 / C62H111N11O12	eMolecules	₹ 7,556.66
Enzo Life Sciences Cyclosporin A (500mg). CAS: 59865-13-3	Enzo Life Sciences	₹ 30,403.75
Cyclosporin A solution	Supelco	₹ 27,038.90
Cyclosporine	Sigma Aldrich	₹ 1,51,182.00
Ciclosporin for system suitability A	Sigma Aldrich	₹ 14,970.98
Ciclosporin	Sigma Aldrich	₹ 16,516.80

Description

General description: Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties.[1] It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation.[2] It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.[3]
Application: These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Biochem/physiol Actions: A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Analysis Note: These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote: To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.