Description

• General description: Salicin is a non-phenolic glucosidic compound[1] extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever.[2] Salicin acts a metabolic precursor for salicylic acid.[3] It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.[4]
• Application: D-(-)-Salicin has been used:to study its in vitro anticoagulant and antiplatelet activities[1]as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant[3][5]as a tastant in taste threshold assay[6]as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei[7]
• Biochem/physiol Actions: D-(−)-Salicin exerts anti-rheumatism and anti-inflammatory activities.[8] It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies.[8] It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK).[8] It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.[8]