Description

• General description: 1-Bromo-2,4,6-tri-tert-butylbenzene (2,4,6-tri-tert-butylbromobenzene) is a hindered aryl bromide.[1] 1-Bromo-2,4,6-tri-tert-butylbenzene on reaction with phenylboronic acid yields α,α-dimethyl-β-phenyl hydrostyrene.[2]
• Application: 1-Bromo-2,4,6-tri-tert-butylbenzene was used in the synthesis of bulky biarylphosphine ligand. This ligand was reported to participate in the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions.[3] It was used to investigate the effect on oligomerization of increased steric bulk in dimethylindium(III) chalcogenolates.[4] It may be used to form α,α-dimethyl-β-phenyl hydrostyrene by reacting with phenylboronic acid.[2]