Description

• General description: 4-Aminothiophenol is a bifunctional aromatic thiol used to form self-assembled monolayers for biosensors. [1]4-Aminothiophenol (p-aminothiophenol, PATP) is an aromatic thiol. The self-assembly of silver and gold nano particles which are interconnected with 4-ATP to form metal-molecule-metal sandwich architecture has been characterized by surface enhanced Raman scattering (SERS) using an off-surface plasmon resonance condition.[2] Chemical transformation of PATP to 4,4-dimercaptoazobenzene (DMAB) has been extensively studied.[3][4]
• Application: 4-Aminothiophenol (4-ATP) was employed as bifunctional molecule to functionalize gold nanoparticles (NPs) used in surface-enhanced Raman spectroscopy (SERS) detection of thrombin by protein recognition.[5]It may be used in the following studies:As a water insoluble ligand in the synthesis of pectin–4-aminothiophenol conjugates.[6]To functionalize gold nanorods (GNR) in the development of GNR nitrite sensor.[7]To form self-assembled monolayers (SAMs) of 4-aminothiophenol in the development of DNA biosensor.[8]As a linker to thiol (SH) functionalize multiwalled carbon nanotubes (MWCNTs).[9]To generate amino terminated self-assembly monolayers(SAMs) on platinum electrode which forms the base for attachment of single-wall carbon nano tubes (SWCTs).[10]