Description

• General description: 5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2.[1] Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs.[2] It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.[3]
• Application: 5-Bromoisatin may be used in the synthesis of the following:N-derivatives of 5-bromoisatin[4][5]N-substituted pyrroles[6]linear polyaryleneoxindoles[7]5-bromodioxindole[8]cinchoninic acid derivatives[9]3-hydroxyoxindole[10]S-benzyldithiocarbazate Schiff Bases[11]5-bromooxindole[12]Morita-Baylis-Hillman adducts of isatin derivatives[13]