8.52309
Fmoc-ACA-OH
Novabiochem®
Manufacturer: Sigma Aldrich
CAS Number: 378247-75-7
Synonym(S): Fmoc-ACA-OH, 7-N-Fmoc-aminocoumarin-4-acetic acid
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 250 MG | 8.52309-250-MG | In Stock | ₹ 13,721.61 |
| 1 G | 8.52309-1-G | In Stock | ₹ 43,130.00 |
8.52309 - 250 MG
In Stock
Quantity
1
Base Price: ₹ 13,721.61
GST (18%): ₹ 2,469.89
Total Price: ₹ 16,191.50
Quality Level
200
product line
Novabiochem®
Assay
≥95.0% (HPLC)≥98% (TLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
aromatic amine
storage temp.
2-8°C
InChI
1S/C26H19NO6/c28-24(29)11-15-12-25(30)33-23-13-16(9-10-17(15)23)27-26(31)32-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22H,11,14H2,(H,27,31)(H,28,29)
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Description
- General description: Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates by Fmoc SPPS. Fmoc-ACA-OH [1] must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled with HATU/collidine [2]. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases [3]. Treatment of the ACC peptide obtained after TFA cleavage with an aqueous base causes facile decarboxylation and formation of the AMC peptide. Associated Protocols and Technical Articles Cleavage and Deprotection Protocols for Fmoc SPPS Chromogenic Labeling of Synthetic Peptides Literature references [1] J. L. Harris, et al. (2000) Proc. Natl. Acad. Sci. USA, 97, 7754. [2] D. J. Maly, et al. (2002) J. Org. Chem., 67, 910. [3] C. M. Salisbury, et al. (2002) J. Am. Chem. Soc., 124, 14868.
- Analysis Note: Color (visual): white to slight yellow to light redAppearance of substance (visual): powderIdentity (IR): passes testPurity (TLC(CMA1)): ≥ 98 %Assay (HPLC, area%): ≥ 95.0 % (a/a)Solubility (1 mmole in 2 ml DMF): clearly solubleTo see the solvent systems used for TLC of Novabiochem® products please click here.
- Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 200
product line: Novabiochem®
Assay: ≥95.0% (HPLC)≥98% (TLC)
form: powder
reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename: Novabiochem®
application(s): peptide synthesis
functional group: aromatic amine
storage temp.: 2-8°C
InChI: 1S/C26H19NO6/c28-24(29)11-15-12-25(30)33-23-13-16(9-10-17(15)23)27-26(31)32-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22H,11,14H2,(H,27,31)(H,28,29)
Quality Level:
200
product line:
Novabiochem®
Assay:
≥95.0% (HPLC)≥98% (TLC)
form:
powder
reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename:
Novabiochem®
application(s):
peptide synthesis
functional group:
aromatic amine
storage temp.:
2-8°C
InChI:
1S/C26H19NO6/c28-24(29)11-15-12-25(30)33-23-13-16(9-10-17(15)23)27-26(31)32-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22H,11,14H2,(H,27,31)(H,28,29)
Quality Level: 200
product line: Novabiochem®
Assay: ≥90.0% (HPLC)
form: powder
reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename: Novabiochem®
application(s): peptide synthesis
functional group: BocFmoc
storage temp.: -10 to -25°C
InChI: __
Quality Level:
200
product line:
Novabiochem®
Assay:
≥90.0% (HPLC)
form:
powder
reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename:
Novabiochem®
application(s):
peptide synthesis
functional group:
BocFmoc
storage temp.:
-10 to -25°C
InChI:
__
Quality Level: 200
product line: Novabiochem®
Assay: __
form: solid
reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename: Novabiochem®
application(s): peptide synthesis
functional group: azide
storage temp.: 15-25°C
InChI: 1S/C19H18N4O4/c20-23-21-10-9-17(18(24)25)22-19(26)27-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,22,26)(H,24,25)/t17-/m0/s1
Quality Level:
200
product line:
Novabiochem®
Assay:
__
form:
solid
reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename:
Novabiochem®
application(s):
peptide synthesis
functional group:
azide
storage temp.:
15-25°C
InChI:
1S/C19H18N4O4/c20-23-21-10-9-17(18(24)25)22-19(26)27-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,22,26)(H,24,25)/t17-/m0/s1
Quality Level: 200
product line: Novabiochem®
Assay: __
form: solid
reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename: Novabiochem®
application(s): peptide synthesis
functional group: alkyne
storage temp.: 15-25°C
InChI: __
Quality Level:
200
product line:
Novabiochem®
Assay:
__
form:
solid
reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename:
Novabiochem®
application(s):
peptide synthesis
functional group:
alkyne
storage temp.:
15-25°C
InChI:
__