Nerve Growth Factor β Human

Description

• General description: HumanKine NGF-β is expressed in human 293 cells as a non-glycosylated, non-disulfide bonded 13 kDa homodimer. NGF-β belongs to the nerve growth factor protein superfamily. It is a key growth factor in target-mediated regulation of peripheral innervation. During development, NGF-β regulates nerve cell death, synaptic connectivity, fiber guidance, and dendritic morphology. The presence of NGF-β in immune cells and endocrine cells as well as in the CNS limbic areas suggests that it may function as an intracellular messenger to regulate the body′s response to stress.
• Application: Nerve Growth Factor β Human has been used as a neurotrophic agent in luciferase reporter assay using mammalian cells.[2]
• Biochem/physiol Actions: Nerve Growth Factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation,[1][3] and survival.[3] Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms.[1] NGFB is known to promote cancer cell proliferation and metastasis. It is associated with lung, breast, prostatic and pancreatic cancers.[4] In animal models, NGFB is observed to prevent cholinergic neuron loss and enhances memory.[5]
• Physical form: Lyophilized from a 0.2 μm filtered solution of 1X PBS
• Analysis Note: The specific activity was determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells (human erythroleukemic indicator cell line).
• Legal Information: 3D Insert is a trademark of 3D Biotek, LLC