5235539
MilliporeSigma™ ESGRO™-2i Selective Medium Kit
provided with a selective GSK3β and Mek 1/2 inhibitors to enhance viability of mouse embryonic stem and iPS cells in the absence of serum and feeder cells. Supports a naive/ground pluripotent state.
Manufacturer: Fischer Scientific
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Content And Storage
Store in dark at -20° C
For Use With (Application)
Stem Cell Culture
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Description
- Two stages of mouse pluripotency have been stabilized to date through in vitro culture
- ‘Naive’ represents the earliest stage, which can be enriched for a purer population, termed ‘ground state’
- Naive most closely approximates embryonic epiblast in the preimplantation blastocyst
- The primed state most closely approximates in vivo immediate postimplantation epiblast
- There are clear differences between these stages in culture, expression, epigenetics (including appropriate X-inactivation) and developmental competence
- The fact that naive mESCs can generate whole animals through tetraploid complementation while primed mESCs cannot, is a particularly compelling reason for heightened expectations from naive hESCs.
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Content And Storage: Store in dark at -20° C
For Use With (Application): Stem Cell Culture
Content And Storage:
Store in dark at -20° C
For Use With (Application):
Stem Cell Culture
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