60-685-0

LIN28 1632, >98%, Tocris Bioscience™

Manufacturer: R&D Systems

CAS Number: 108825-65-6

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Pack Size SKU Availability Price
Each of 1 60-685-0-Each-of-1 In Stock ₹ 93,944.88

60-685-0 - Each of 1

₹ 93,944.88

In Stock

Quantity

1

Base Price: ₹ 93,944.88

GST (18%): ₹ 16,910.078

Total Price: ₹ 1,10,854.958

Chemical Name or Material

N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

Purity Grade Notes

>98%

Quantity

50 mg

Formula Weight

281.31

CAS

108825-65-6

Linear Formula

C15H15N5O

Solubility Information

Soluble to 100mM in DMSO and to 100mM in ethanol

Other Options

Image Product Name Manufacturer Price Range
CS-0059071
Lin28-let-7 antagonist 1
ChemScene ₹ 9,411.60 - ₹ 37,133.04
AD41805
108825-65-6 | Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-
A2B Chem ₹ 1,967.88 - ₹ 28,919.28

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Description

  • Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM)
  • Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA
  • Lin28 1632 inhibits stemness and induces differentiation of murine ESCs
  • Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines
  • Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro
  • Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity
  • Lin28 1632 is also bromodomain inhibitor
  • Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

SAFETY INFORMATION

  • Recommended Storage : Store at 4°C

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R&D Systems

60-685-0

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Chemical Name or Material:
N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

Purity Grade Notes:
>98%

Quantity:
50 mg

Formula Weight:
281.31

CAS:
108825-65-6

Linear Formula:
C15H15N5O

Solubility Information:
Soluble to 100mM in DMSO and to 100mM in ethanol

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Fischer Scientific

60-695-0041

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25 Tests

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__

CAS:
__

Linear Formula:
__

Solubility Information:
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Img

Fischer Scientific

60-695-0042

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Chemical Name or Material:
__

Purity Grade Notes:
__

Quantity:
100 Tests

Formula Weight:
__

CAS:
__

Linear Formula:
__

Solubility Information:
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Epredia™

60-7

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Chemical Name or Material:
__

Purity Grade Notes:
__

Quantity:
__

Formula Weight:
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CAS:
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Linear Formula:
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Solubility Information:
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