Description

• General description: Isobutyraldehyde is an α,α-disubstituted aldehyde.[1] It is an important raw material for the manufacture of various industrially important chemicals. It may be produced from CO2 and overexpression of ribulose 1,5-bisphosphate carboxylase/oxygenase employing genetically engineered strain of Synechococcus elongatus PCC7942.[2] Enantioenriched γ-nitroaldehydes are obtained from the conjugate addition reaction between isobutyraldehyde with nitroalkenes in the presence of chiral organocatalysts.[3]
• Application: Isobutyraldehyde may be used in the synthesis of the following compounds:N-cyclohrxyl-α-dimethylaminoisovalerarnide[1]N′-cyclohexyl-N,N-dimethyl-α-dimethylaminoisovaleramidine[1]α-acetoxy-N-cyclohexylisovaleramide[1]acetic anhydride[1]N-cyclohexyl-a-formyloxyisovaleramide[1]cyclic carbonates[4]hydroxypivaldehyde, which is useful for the preparation of neopentyl glycol (NPG)[5]It may also be employed for the microbial synthesis of isobutanol.[6]