Description

• General description: Acetophenone is an aromatic ketone used in the synthesis of alcohol by catalytic hydrogenation, and also in perfumery.[1][2]Acetophenone (AP, methyl phenyl ketone) is a common industrial solvent.[3] It can be synthesized from 1-phenylethanol in the presence of PdAu-NPs-TiO2 (titanium dioxide-supported palladium gold bimetallic nanoparticles) hybrid.[4] Its vacuum ultraviolet absorption spectrum shows absorption bands at 196, 191, 179 and 167mμ.[5] AP reacts with α-naphtylphenylsilane in the presence of N-chelate ligands based on chiral oxazolines to undergo hydrosilylation with high enantioselectivity.[6] It can also undergo hydrogenation reaction in the presence of different transition metal catalysts under different conditions.[7][8][9]
• Application: Acetophenone was used to induce peak currents in M71 neurons using voltage clamp.[10] It may be used in the synthesis of N-(1-phenylethyl)formamide, via Leuckart reaction.[11]
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