Description

• General description: (R)-(+)-BINAP is a chiral diphosphine ligand that exhibits high enantioselectivity and reactivity in various organic reactions.[1](R)-(+)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene is an axially dissymmetric bis(triaryl)phosphine ligand for asymmetric reactions.[2]
• Application: Useful ligand for transition metal catalyzed asymmetric reactions, including hydrogenation[3] and disilylation.[4] 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl and its rhodium and ruthenium derivatives are highly selective homogeneous catalysts used for the reduction of aryl ketones,[5] β-keto esters,[6] and α-amino ketones.[7] They have also been used for asymmetric hydrogenation[8] and hydroformylation of olefins,[9] asymmetric Heck reactions,[10] and asymmetric isomerizations of allyls.[11][12]Complex with Ag(I) used to catalyze an asymmetric aldol reaction between alkenyl trichloroacetates and aldehydes.[13] Also used with Ag(I) to catalyze an enantioselective hetero-Diels-Alder reaction of azo compounds.[14]