Description

• General description: Scandium(III) triflate is an extremely active, efficient, recoverable and reusable acylation catalyst.[1] Its an important catalyst for the Friedel-Crafts acylation, Diels-Alder reactions and other carbon-carbon bond-forming reactions.[2] It also stereochemically catalyzes the radical polymerization of acrylates.[3] Scandium(III) triflate complex of (4′S,5′S)-2,6-bis[4′-(triisopropylsilyl)oxymethyl-5′-phenyl-1′,3′-oxazolin-2′-yl]pyridine has been employed as catalyst for the asymmetric Friedel-Crafts reaction between substituted indoles and methyl (E)-2-oxo-4-aryl-3-butenoates.[4]
• Application: Scandium(III) triflate was used as a catalyst in:Hydrothiolation reaction of aromatic and aliphatic thiols.[5]Selective two-electron reduction of O2 by ferrocene derivatives.[6]Vinylogous Friedel-Crafts alkylation of indoles and pyrroles in water.[7]Synthesis of β-cyanoketones.[8]Combination with triethylsilane to reductively open functionalized pyranoside rings.[9] The key steps of synthesis of bullvalone via a stabilized sulfur ylide.[10]