Description

• General description: (2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone is a chiral imidazolidinone organocatalyst, developed by MacMillan and co-workers.[1]
• Application: (2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone is a second-generation MacMillan catalyst, which can be used as a chiral organocatalyst in: The chiral transformation reaction, including Friedel-Crafts and Mukaiyama-Michael reactions.[2] The preparation of substituted spiroundecenetriones via asymmetric domino Knoevenagel/Diels-Alder reactions.[3] The asymmetric synthesis of β-hydroxy aldehydes and their dimethylacetals via aldehyde-aldehyde aldol condensation reaction.[4] The enantioselective α-fluorination of aldehydes using N-fluorobenzenesulfonamide as a fluorinating agent.[5] The stereoselective preparation of (oxomethyl)oxabicyclo[3.2.1]octenones and tricyclic pyrroles via [4+3] cycloaddition of (trialkylsiloxy)pentadienals to furans.[6]
• Features and Benefits: Advantages of MacMillan imidazolidinone organocatalysts:[1]Superior enantiocontrol in numerous transformationsHigh activities at low catalyst loadingsExtraordinary functional group tolerance
• Legal Information: U.S. Pat. 6,369,243 and related patents apply. For research purposes only.