Description

• Application: Under a dual catalytic copper/photoredox manifold, the Mes-Umemoto reagent has been demonstrated to be an excellent photocatalyst for the trifluoromethylation of alkyl halides and aryl halides to yield alkyl-CF3 and aryl-CF3 in high yields. In both cases, these reactions exhibit wide substrate scope with good functional group tolerance. More specifically, a variety of 5-membered and 6-membered heteroaryl halides can be readily converted to the corresponding trifluoromethylheteroarenes under mild conditions. For trifluoromethylation reactions, use with dMesSCF3 (901466) and supersilanol (902489).Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
• Other Notes: A radical approach to the copper oxidative addition problem:Trifluoromethylation of bromoarenesCatalytic alkylation of remote C-H bonds enabled by proton-coupled electron transfer