901511
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
≥95%
Manufacturer: Sigma Aldrich
CAS Number: 2097971-11-2
Synonym(S): (2S,4R)-1-((S)-14-Amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 901511-50-MG | In Stock | ₹ 51,860.00 |
901511 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 51,860.00
GST (18%): ₹ 9,334.80
Total Price: ₹ 61,194.80
ligand
VH032
Quality Level
100
Assay
≥95%
form
powder or crystals
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | VH 032 amide-PEG3-amine | R&D Systems | ₹ 21,988.92 | |
 | eMolecules Medchem Express / (SRS)-AHPC-PEG3-NH2 (hydrochloride) / 10mg / 475641365 / HY-103602 / / 2097971-11-2 / [null] / 656.240 / C30H46ClN5O7S | eMolecules | ₹ 10,075.55 | |
 | (S,R,S)-AHPC-PEG3-NH2 hydrochloride | ChemScene | ₹ 3,850.20 - ₹ 2,65,236.00 | |
 | 2097971-11-2 | (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamidehydrochloride | A2B Chem | ₹ 9,753.84 - ₹ 1,10,543.52 |
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Description
- Application: Protein degrader builiding block (S,R,S)-AHPC-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor ScaffoldsDegradation of the BAF Complex Factor BRD9 by Heterobifunctional LigandsAssessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and DegradationTargeted Protein Degradation by Small MoleculesImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: VH032
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl
ligand:
VH032
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl
ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCN)=O)=O)NC1=O.Cl
ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN)=O)=O)NC1=O.Cl
ligand: VH032
Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: alkyne
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCC#C)=O)=O
ligand:
VH032
Quality Level:
100
Assay:
≥95%
form:
powder
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
alkyne
storage temp.:
2-8°C
SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCC#C)=O)=O