901525
Pomalidomide-C9-CO2H
≥95%
Manufacturer: Sigma Aldrich
CAS Number: 2243000-24-8
Synonym(S): 10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 901525-50-MG | In Stock | ₹ 46,760.00 |
901525 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 46,760.00
GST (18%): ₹ 8,416.80
Total Price: ₹ 55,176.80
ligand
pomalidomide
Quality Level
100
Assay
≥95%
form
powder or crystals
reaction suitability
reactivity: amine reactivereagent type: ligand-linker conjugate
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Related Products
Description
- Application: Protein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationnPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: amine reactivereagent type: ligand-linker conjugate
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: amine reactivereagent type: ligand-linker conjugate
functional group:
carboxylic acid
storage temp.:
2-8°C
SMILES string:
OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
ligand: pomalidomide
Quality Level: 100
Assay: 95%
form: powder or crystals
reaction suitability: reactivity: amine reactivereagent type: ligand-linker conjugate
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O
ligand:
pomalidomide
Quality Level:
100
Assay:
95%
form:
powder or crystals
reaction suitability:
reactivity: amine reactivereagent type: ligand-linker conjugate
functional group:
carboxylic acid
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O
ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: amine reactivereagent type: ligand-linker conjugate
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCC(O)=O)=O)NC1=O
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: amine reactivereagent type: ligand-linker conjugate
functional group:
carboxylic acid
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCC(O)=O)=O)NC1=O
ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: alkyne
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCC#C)=O)=O)NC1=O
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
alkyne
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCC#C)=O)=O)NC1=O