911755
C5 Lenalidomide-PEG5-NH2 hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): 17-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-3,6,9,12,15-pentaoxaheptadecanamide hydrochloride, C5 Lenalidomide conjugate, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 911755-50-MG | In Stock | ₹ 48,300.00 |
911755 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 48,300.00
GST (18%): ₹ 8,694.00
Total Price: ₹ 56,994.00
ligand
C5 Lenalidomide
Quality Level
100
form
powder or crystals
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCN)=O)=CC=C31.Cl
Related Products
Description
- Application: Protein degrader building block C5 Lenalidomide-PEG5-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector and a PEGylated crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationBuilding PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: C5 Lenalidomide
Quality Level: 100
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCN)=O)=CC=C31.Cl
ligand:
C5 Lenalidomide
Quality Level:
100
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCN)=O)=CC=C31.Cl
ligand: __
Quality Level: 100
form: (Powder or crystals or solid or chunks)
reaction suitability: __
functional group: __
storage temp.: 2-8°C
SMILES string: __
ligand:
__
Quality Level:
100
form:
(Powder or crystals or solid or chunks)
reaction suitability:
__
functional group:
__
storage temp.:
2-8°C
SMILES string:
__
ligand: __
Quality Level: __
form: powder
reaction suitability: reagent type: catalystreaction type: Cross Couplings
functional group: __
storage temp.: __
SMILES string: Cl[Ni]1(P(C(C2)(O3)C)(C4=CC=CC=C4P(C5=CC=CC=C5)1C6=CC=CC=C6)[C@@](C[C@]3(OC27C)C)(O7)C)C(C=CC=C8)=C8C
ligand:
__
Quality Level:
__
form:
powder
reaction suitability:
reagent type: catalystreaction type: Cross Couplings
functional group:
__
storage temp.:
__
SMILES string:
Cl[Ni]1(P(C(C2)(O3)C)(C4=CC=CC=C4P(C5=CC=CC=C5)1C6=CC=CC=C6)[C@@](C[C@]3(OC27C)C)(O7)C)C(C=CC=C8)=C8C
ligand: __
Quality Level: __
form: powder
reaction suitability: reagent type: catalystreaction type: Cross Couplings
functional group: __
storage temp.: __
SMILES string: CC(C1CCC2=C1C=CC=C2)(C)C.C[Pd](Cl)P(C(C)(C)C)(C(C)(C)C)C(C)(C)C.CC
ligand:
__
Quality Level:
__
form:
powder
reaction suitability:
reagent type: catalystreaction type: Cross Couplings
functional group:
__
storage temp.:
__
SMILES string:
CC(C1CCC2=C1C=CC=C2)(C)C.C[Pd](Cl)P(C(C)(C)C)(C(C)(C)C)C(C)(C)C.CC