919489
CCW16-C6-PEG3-butyl-BocNH
Manufacturer: Sigma Aldrich
Synonym(S): tert-butyl (6-(2-(2-((6-(4-(4-(N-Benzyl-2-chloroacetamido)phenoxy)phenoxy)hexyl)oxy)ethoxy)ethoxy)hexyl)carbamate, Crosslinker-E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, RNF4-targeting building block, Template for synthesis of targeted protein degrader
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 919489-50-MG | In Stock | ₹ 64,787.63 |
919489 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 64,787.63
GST (18%): ₹ 11,661.773
Total Price: ₹ 76,449.403
ligand
CCW16
Quality Level
100
form
viscous liquid
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCCCCCOCCOCCOCCCCCCNC(OC(C)(C)C)=O)C=C3
Related Products
Description
- Application: Protein degrader building block CCW16-C6-PEG3-butyl-BocNH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a RING finger protein 4 (RNF4)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationCovalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation ApplicationsTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: CCW16
Quality Level: 100
form: viscous liquid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCCCCCOCCOCCOCCCCCCNC(OC(C)(C)C)=O)C=C3
ligand:
CCW16
Quality Level:
100
form:
viscous liquid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCCCCCOCCOCCOCCCCCCNC(OC(C)(C)C)=O)C=C3
ligand: __
Quality Level: 100
form: liquid
reaction suitability: __
functional group: amine
storage temp.: 2-8°C
SMILES string: __
ligand:
__
Quality Level:
100
form:
liquid
reaction suitability:
__
functional group:
amine
storage temp.:
2-8°C
SMILES string:
__
ligand: __
Quality Level: 100
form: liquid
reaction suitability: __
functional group: amine
storage temp.: 2-8°C
SMILES string: __
ligand:
__
Quality Level:
100
form:
liquid
reaction suitability:
__
functional group:
amine
storage temp.:
2-8°C
SMILES string:
__
ligand: __
Quality Level: 100
form: powder
reaction suitability: reagent type: catalystreaction type: Cross Couplingsreagent type: ligand
functional group: phosphine
storage temp.: __
SMILES string: __
ligand:
__
Quality Level:
100
form:
powder
reaction suitability:
reagent type: catalystreaction type: Cross Couplingsreagent type: ligand
functional group:
phosphine
storage temp.:
__
SMILES string:
__